|
KMID : 0981820070270010034
|
|
Korean Journal of Laboratory Medicine
2007 Volume.27 No. 1 p.34 ~ p.39
|
|
|
Assessment of the Accuracy and Precision of Cystatin C-based GFR Estimates and Cr-based GFR Estimates in Comparison with Cr51-EDTA GFR
|
|
Kim Yun-hee
Min Won-Ki
Lyu Jin-Sug
|
|
|
Abstract
|
|
|
Background : Cystatin C (cysC) is said to be an ideal marker for glomerular filtration rate (GFR), independent of external factors such as age, nutrition and inflammation. The authors compared the accuracy and precision of cysC-based and creatinine (Cr)-based GFR estimates using Cr51-EDTA GFR method as a reference.
Methods : Serum concentrations of cysC and Cr were measured in adults over 17 yr (n=170) and children below 17 yr (n=79) who had had GFR estimated by Cr51-EDTA method. CysC-based GFR was estimated by the formula of Thierry [CysC-based GFR estimates (mL/min/1.73 m2)=78×(1/cysC, in mg/L)+4] and Cr-based GFR by the formula of modified Modification of Diet in Renal Disease [MDRD II, Cr-based GFR estimates (mL/min/1.73 m2)=186×(Scr)-1.154×(Age)-0.203×0.742 (for a female patient)×1.212 (for a black patient).
Results : In comparison with Cr51-EDTA GFR, in children below 17 yr, the bias±standard deviation (SD) of cysC-based and Cr-based GFR estimates were 7.5±6.1 and 106.5±98.2, respectively, in the range of below 90 of Cr51-EDTA GFR (mL/min/1.73 m2), and 33.7±33.0 and 174.4±18.8 in the range of over 90. In adults over 17 yr, the respective figures were 13.1±11.0 and 17.4±29.8 in below 90, and 21.2±20.1 and 83.6±108.8 in over 90 of Cr51-EDTA GFR.
Conclusions : CysC-based GFR estimates show acceptable ranges of biases over the whole age and GFR ranges. CysC-based GFR estimates is considered to be the marker for GFR, which could be used without limitation of age and GFR ranges. (Korean J Lab Med 2007;27:34-9)
|
|
|
KEYWORD
|
|
|
Cr51-EDTA GFR, Cystatin C-based GFR estimates, Creatinine-based GFR estimates
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|